Anti-CD59 Mouse Monoclonal Antibody (CF488A) [clone: MACIF/629]

Supplier: Biotium
BNC880629-500 BNC880629-100
BNC880629-500EA 560 EUR
BNC880629-500 BNC880629-100
Anti-CD59 Mouse Monoclonal Antibody (CF488A) [clone: MACIF/629]
Antibodies
Reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This MAb is useful for study on GPI-anchored proteins, PNH and CD59 functions. CD59 is widely distributed on cells in all tissues. The expression of CD59 on erythrocytes is important for their survival.

Type: Primary
Antigen: CD59
Clonality: Monoclonal
Clone: MACIF/629
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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