Anti-GPC3 Mouse Monoclonal Antibody (Purified) [clone: 1G12]

Supplier: Biotium
BNUB0862-500 BNUB0862-100
BNUB0862-500EA 511 EUR
BNUB0862-500 BNUB0862-100
Anti-GPC3 Mouse Monoclonal Antibody (Purified) [clone: 1G12]
Antibodies
Recognizes a protein, which is identified as HGAL. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. HGAL is specifically expressed in germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the inter-follicular and para-cortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL).

Type: Primary
Antigen: GPC3
Clonality: Monoclonal
Clone: 1G12
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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