Anti-UACA Mouse Monoclonal Antibody (CF640R) [clone: UACA/1222]

Supplier: Biotium
BNC401222-500 BNC401222-100
BNC401222-500EA 560 EUR
BNC401222-500 BNC401222-100
Anti-UACA Mouse Monoclonal Antibody (CF640R) [clone: UACA/1222]
Antibodies
UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

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