You Searched For: Phenylboronic+acid+pinacol+ester

Description: Recognizes a 77-85 kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.

Catalog Number: BNC940419-100

UOM: 1 * 100 µl

Supplier: Biotium

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Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Catalog Number: BOSSBS-1813R-CY7

UOM: 1 * 100 µl

Supplier: Bioss

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Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Catalog Number: BOSSBS-1813R-CY5

UOM: 1 * 100 µl

Supplier: Bioss

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Description: Anti-Lysine Mouse Monoclonal Antibody

Catalog Number: BIRBORB67345-25

UOM: 1 * 25 µG

Supplier: Biorbyt

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Description: Anti-PLOD3 Rabbit Polyclonal Antibody

Catalog Number: USBI040182

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Poly-D-lysine (PDL) is a synthetic molecule used as a coating to enhance cell attachment to plastic and glass surfaces. It has been used to culture a wide variety of cell types, particularly neurons, glial cells, and transfected cells.

Catalog Number: 734-1102

UOM: 1 * 20 mg

Supplier: Corning

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Description: Anti-Lysine Rabbit Polyclonal Antibody (Biotin)

Catalog Number: BIRBORB67532-400

UOM: 1 * 400 µG

Supplier: Biorbyt

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Description: Anti-pan methyl Lysine Rabbit Polyclonal Antibody (FITC (Fluorescein))

Catalog Number: BIRBORB103175-100

UOM: 1 * 100 µG

Supplier: Biorbyt

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Description: There is approximately one HBr or HCl per lysine unit. The HBr/HCl allows it to be a crystalline solid and soluble in water. To remove the HBr/HCl, solubilise the product in a neutral buffer and dialyse away the salts.

Catalog Number: ICNA0215017625

UOM: 1 * 25 mg

Supplier: MP Biomedicals

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Description: Anti-Acetylated Lysine Rabbit Polyclonal Antibody

Catalog Number: ST1027-50

UOM: 1 * 50 µl

Supplier: Merck Millipore (Oncogene)

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Description: JMJD2B is a 1,064 amino acid protein encoded by the human gene JMJD2B. JMJD2B belongs to the JMJD2B histone demethylase family and contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers and two Tudor domains. The two Tudor domains recognize and bind methylated histones and have an interdigitated structure; the unusual fold is required for its ability to bind methylated histone tails. JMJD2B is a histone demethylase that specifically demethylates Lys 9 residues of Histone H3, thereby playing a role in histone code. It does not demethylate Histone H3 Lys 4, H3 Lys 27, H3 Lys 36 or H4 Lys 20, however, and is only able to demethylate trimethylated H3 Lys-9 and has weaker activity than JMJD2A, JMJD2C and JMJD2D. JMJD2B demethyl-ation of Lysine residues will generate formaldehyde and succinate. JMJD2B is a ubiquitously expressed nuclear protein.

Catalog Number: BOSSBS-12200R

UOM: 1 * 100 µl

Supplier: Bioss

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Description: Anti-KAT2B Rabbit Polyclonal Antibody

Catalog Number: USBI039716

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Reacts with a protein of ~66 kDa, identified as bovine serum albumin (BSA). It is a high affinity antibody and can be used for detection of traces of BSA. Bovine serum albumin (BSA) is an abundant plasma protein in cows that is important for maintaining osmotic pressure in blood plasma for proper distribution of body fluids between intravascular compartments and body tissues. BSA is a common buffer component for immunoglobulin type assays due to good solubility characteristics for water, Ca2 , Na , K , fatty acids, hormones and bilirubin. BSA makes up about half of the protein in plasma and represents the most stable and soluble protein in the plasma. It is a suitable reagent for laboratories developing immunoassays, mostly due to its availability, solubility and the numerous functional groups present for coupling. The BSA component contains several lysines that are capable of reacting with conjugation sites of linkers, making it applicable as a carrier protein for antigenic compounds.

Catalog Number: BNC470398-100

UOM: 1 * 100 µl

Supplier: Biotium

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Description: Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein), also designated MEN, functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. It is also thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, with lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary. ELL3 is a 397 amino acid nuclear protein that functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Though similar to ELL and ELL2, ELL3 is exclusively expressed in testis.

Catalog Number: BOSSBS-8560R-A488

UOM: 1 * 100 µl

Supplier: Bioss

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Description: Anti-Carboxy Methyl Lysine Goat Polyclonal Antibody

Catalog Number: BIRBORB25784-1

UOM: 1 * 1 mg

Supplier: Biorbyt

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Description: Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein), also designated MEN, functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. It is also thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, with lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary. The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes that undergo translocation with the MLL gene on chromosome 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia, also designated ALL-1 and HRX) regulates embryonal and hematopoietic development.

Catalog Number: BOSSBS-8515R-CY5

UOM: 1 * 100 µl

Supplier: Bioss

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