You Searched For: N-Acetylneuraminic+acid

Catalog Number: (PRSI91-729)

Supplier: ProSci Inc.

Description: Sialate O-Acetylesterase (SIAE) belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. SIAE is widely expressed with high expression levels in the testis, prostate, and colon. SIAE catalyses N-acetyl-O-acetylneuraminate and H2O to N-acetylneuraminate and acetate. SIAE removes O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. SIAE down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for immunological tolerance. Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.

UOM: 1 * 50 µG

Supplier: MP Biomedicals

Description: N-Acetyl-β-D-mannosamine hydrate is used as a substrate to identify, differentiate and characterise enzymes such as N-acetyl-glucosamine epimerase(s) and aldolase(s). N-Acetyl-D-mannosamine is used for the synthesis of of N-acetylneuraminic acid.

Catalog Number: (PRSI26-232)

Supplier: ProSci Inc.

Description: Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins.Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).

UOM: 1 * 50 µG

Catalog Number: (PRSI92-137)

Supplier: ProSci Inc.

Description: Sialic Acid Synthase (NANS) is an enzyme that contains one AFP-like domain. NANS is ubiquitous and plays a role in the biosynthetic pathways of sialic acids. NANS produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). It also can use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.

UOM: 1 * 50 µG

Catalog Number: (PRSI26-355)

Supplier: ProSci Inc.

Description: CMAS is an enzyme that catalyzes the activation of Neu5Ac to Cytidine 5-prime-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides the substrate required for the addition of sialic acid. Sialic acids of cell surface glycoproteins and glycolipids play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development, and changes with stages of differentiation. Studies of a similar murine protein suggest that this protein localizes to the nucleus.The enzyme encoded by this gene catalyzes the activation of Neu5Ac to Cytidine 5-prime-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides the substrate required for the addition of sialic acid. Sialic acids of cell surface glycoproteins and glycolipids play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development, and changes with stages of differentiation. Studies of a similar murine protein suggest that this protein localizes to the nucleus.

UOM: 1 * 50 µG

Catalog Number: (PRSI5169)

Supplier: ProSci Inc.

Description: ST3gal6 Antibody: Sialyltransferases catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determinants of carbohydrate structures, such as the sialyl-Lewis X determinants, and are widely distributed in many cell types. However, cancer cells often express more heavily sialylated glycans on their cell surface and this feature sometimes correlates with invasiveness. In contrast, expression of ST3gal6, a member of the sialyltransferase family that sialylates type II lactosamine structures on glycoproteins and glycolipids, was found to be significantly decreased by hypermethylation of the gene in gastrointestinal cancer. At least three isoforms of ST3gal6 are known to exist.

UOM: 1 * 100 µG

Catalog Number: (USBI133894)

Supplier: US Biological

Description: Anti-ST3GAL2 Mouse Monoclonal Antibody [clone: 1E12]

UOM: 1 * 100 µG

Catalog Number: (USBI042352-BIOTIN)

Supplier: US Biological

Description: Anti-ST6GAL2 Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 200 µl

Catalog Number: (USBI133900)

Supplier: US Biological

Description: Anti-ST6GAL1 Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

Catalog Number: (PRSIXW-8145)

Supplier: ProSci Inc.

Description: FUNCTION: Involved in the production of GD3 and GT3 from GM3.
CATALYTIC ACTIVITY: CMP-N-acetylneuraminate + beta-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + beta-N-acetylneuraminyl-2,8-beta-N-acetylneuraminyl-2,3-beta-D-galactosyl-R.
SIMILARITY: Belongs to the glycosyltransferase 29 family.
PATHWAY: Glycosylation.
SUBCELLULAR LOCATION: Golgi apparatus; Golgi membrane; single-pass type II membrane protein

UOM: 1 * 50 µG

Supplier: Merck

Description: 2-Oxoglutaric acid

MSDS

Supplier: Merck

Description: Amidosulphonic acid, Supelco®

Catalog Number: (47863.)

Supplier: Merck

Description: L(+)-Ascorbic acid

UOM: 1 * 1 items

MSDS

Catalog Number: (1.04633.0500)

Supplier: Merck

Description: Phosphinic acid (Hypophosphorous acid) 50%, Supelco®

UOM: 1 * 500 mL

MSDS

Supplier: Merck

Description: p-Anisic acid, Supelco®

Catalog Number: (21639-5ML)

Supplier: Merck

Description: Caprylic acid, Supelco®

UOM: 1 * 5 mL