You Searched For: 4-(Trifluoromethyl)pyridine-2-carboxylic acid methyl ester

Catalog Number: (PRSI33-219)

Supplier: ProSci Inc.

Description: This antibody is specific for a protein of 36 kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

UOM: 1 * 100 µG

New Product

Catalog Number: (PRSI47-129)

Supplier: ProSci Inc.

Description: Thymidylate synthase (TS) is anintracellular enzyme critical for de novosynthesis of DNA. In cancer,expression of TS is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of TS activity. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma and is usually predictive of shortened survival time.

UOM: 1 * 100 µG

Supplier: Honeywell Chemicals

Description: HMDS (1,1,1,3,3,3-hexamethyldisilazane)

Catalog Number: (41716-5ML)

Supplier: Merck

Description: N,N-Dimethyl-1,1,1-trimethylsilylamine, Supelco®

UOM: 1 * 5 mL

Catalog Number: (HYPETS-84770)

Supplier: Thermo Fisher Scientific

Description: HMDS (1,1,1,3,3,3-hexamethyldisilazane)

UOM: 1 * 25 g

Catalog Number: (APOSOR350390-1G)

Supplier: APOLLO SCIENTIFIC

Description: 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2-((trimethylsilyl)oxy)propan-2-yl)pyridine

UOM: 1 * 1 g

Catalog Number: (PRSI30-425)

Supplier: ProSci Inc.

Description: TYMS catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-47 CR601528.1 1-47 48-1099 X02308.1 14-1065 1100-1603 BC083512.1 1067-1570

UOM: 1 * 50 µG

Supplier: Thermo Scientific

Description: Poly(methylhydrosiloxane) trimethylsilyl terminated

Catalog Number: (PRSI33-918)

Supplier: ProSci Inc.

Description: Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

UOM: 1 * 100 µG

New Product

Catalog Number: (MOLEM37003218)

Supplier: Molekula

Description: HMDS (1,1,1,3,3,3-hexamethyldisilazane)

UOM: 1 * 500 mL

 This is a MarketSource item. Additional charges may apply

Supplier: APOLLO SCIENTIFIC

Description: Trimethylsilylacetylene 97%

Supplier: Alfa Aesar

Description: 2-(Trimethylsilylethynyl)pyridine ≥97%

Supplier: Alfa Aesar

Description: 3-Trimethylsilylpropynal ≥97%

MSDS Certificates

Supplier: Thermo Scientific

Description: Trimethylsilylacetylene 98%

Supplier: Alfa Aesar

Description: Trimethylsilylacetylene ≥98%

Supplier: Alfa Aesar

Description: N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine 94%