You Searched For: O,O\\\\\\\\\\\'-Bis(trimethylsilyl)-5-fluorouracil

Catalog Number: (03738-100MG)

Supplier: Merck

Description: Organic Standard, 5-Fluorouracil

UOM: 1 * 100 mg

Catalog Number: (PHR1227-500MG)

Supplier: Merck

Description: Organic Standard, Fluorouracil

UOM: 1 * 500 mg

Catalog Number: (04541-50MG)

Supplier: Merck

Description: Organic Standard, 5-Fluorouracil

UOM: 1 * 50 mg

Supplier: APOLLO SCIENTIFIC

Description: Antineoplastic agent. Not USP. Not for drug use.

Supplier: MACHEREY-NAGEL

Description: BSTFA is a powerful trimethylsilyl donor with approximately the same donor strength as the nonfluorinated analog BSA. Advantage of BSTFA over BSA: greater volatility of its reaction products (particularly useful for GC of some lower boiling TMS amino acids).

Supplier: MACHEREY-NAGEL

Description: BSA is a strong silylation reagent that forms very stable TMS derivatives with a large variety of compounds, e.g., non-sterically hindered alcohols, carboxylic acids, phenols, enols, steroids, (biogenic) amines and alkaloids.

Supplier: MACHEREY-NAGEL

Description: Silyl-271 will derivatise all hydroxyl groups in any position. Useful in multiderivatisation schemes involving hydroxyl or amine groups.

Supplier: MACHEREY-NAGEL

Description: Silyl-991 is recommended for silylation of fatty acid amides, hindered hydroxyls and other compounds which are difficult to silylate (e.g., secondary alcoholes and amines).

Catalog Number: (APOSPC0704-25G)

Supplier: APOLLO SCIENTIFIC

Description: 2-Ethoxy-5-fluoro-4-pyrimidinone

UOM: 1 * 25 g

Supplier: Thermo Scientific

Description: 5-Fluoro-5'-deoxyuridine (Doxifluridine)

Supplier: USP

Description: USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.

Supplier: APOLLO SCIENTIFIC

Description: 5-Fluoroorotic acid

Supplier: APOLLO SCIENTIFIC

Description: (+)-5-Fluoro-5'-deoxyuridine

Supplier: APOLLO SCIENTIFIC

Description: Useful in the selection of orotidine-5'-phosphatedecarboxylase mutants in Saccharomycescerevisiae: Genetics, 1984, 107, 179.

Supplier: USP

Description: USP Reference Standards are specified for use in conducting official USP–NF tests and assays. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.

Catalog Number: (BOSSBS-8288R-A555)

Supplier: Bioss

Description: Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.

UOM: 1 * 100 µl