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Catalog Number: (BOSSBS-13173R-FITC)
Supplier: Bioss
Description: The Component of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex plays an important role in the 3'-end formation of pre-mRNA. This complex recognizes the AAUAAA signal sequence and interacts with poly(A) polymerase to process and add to the poly(A) tail. FIP1L1 (FIP1-like 1), also known as Pre-mRNA 3'-end-processing factor FIP1, FIP1 (Factor interacting with PAP) and RHE (Rearranged in hypereosinophilia), is a 594 amino acid nuclear protein that is a component of the CPSF complex. Within the complex, FIP1L1 contributes to the poly(A) recognition and stimulates poly(A) addition. Fusion of the genes encoding FIP1L1 and PDGFRA due to an interstitial deletion on chromosome 4q12 is the cause of hypereosinophilia syndrome, a rare blood disorder characterized by continuous overproduction of eosinophils in the bone marrow that leads to tissue infiltration and organ damage. There are three isoforms of FIP1L1 that are produced as a result of alternative splicing events.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-13173R-A488)
Supplier: Bioss
Description: The Component of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex plays an important role in the 3'-end formation of pre-mRNA. This complex recognizes the AAUAAA signal sequence and interacts with poly(A) polymerase to process and add to the poly(A) tail. FIP1L1 (FIP1-like 1), also known as Pre-mRNA 3'-end-processing factor FIP1, FIP1 (Factor interacting with PAP) and RHE (Rearranged in hypereosinophilia), is a 594 amino acid nuclear protein that is a component of the CPSF complex. Within the complex, FIP1L1 contributes to the poly(A) recognition and stimulates poly(A) addition. Fusion of the genes encoding FIP1L1 and PDGFRA due to an interstitial deletion on chromosome 4q12 is the cause of hypereosinophilia syndrome, a rare blood disorder characterized by continuous overproduction of eosinophils in the bone marrow that leads to tissue infiltration and organ damage. There are three isoforms of FIP1L1 that are produced as a result of alternative splicing events.
UOM: 1 * 100 µl


Catalog Number: (APOSOR937218-500G)
Supplier: APOLLO SCIENTIFIC
Description: (±)-1-Octen-3-ol 95%
UOM: 1 * 500 g


Supplier: APOLLO SCIENTIFIC
Description: Potassium vinyltrifluoroborate 97%

Supplier: Brady
Description: These vinyl adhesive labels help send a clear message to workers when a machine is down for service or maintenance.

Catalog Number: (BOSSBS-9623R-A750)
Supplier: Bioss
Description: Poly (ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly (ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors; a process that, when repeated multiple times, leads to the formation of poly (ADPribose) chains on the protein. The presence of these chains alters the function of the target protein and promotes cell survival. PARP proteins are implicated in a variety of diseases, including cancer, neurodegenerative and inflammatory disorders. PARP-16 is a 322 amino acid poly (ADP-ribose) polymerase protein localised to the membrane. Expressed as three isoforms produced by alternative splicing, PARP-16 contains one PARP catalytic domain.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-9435R-CY5.5)
Supplier: Bioss
Description: Polyadenylation of the 3-prime ends of eukaryotic mRNAs is a key event that takes place in the nucleus during maturation of mRNA. The reaction includes endoribonucleolytic cleavage of the pre-RNA at the poly(A) site that leads to synthesis of the poly(A) tail at the 3-prime end of the upstream cleavage product. The poly(A) polymerase (PAP) is required The adenosine addition reaction depends on poly(A) polymerase (PAP) activity. The testis express PAP-beta (TPAP) in the cytoplasm of spermatogenic cells. The adenosine addition function of PAP-beta plays a critical role in male germ cell production. PAP-beta-deficient transgenic mice display impaired expression of haploid-specific genes that are necessary for spermatogenesis. The intronless gene encoding human PAP-beta maps to chromosome 7p22.3.
UOM: 1 * 100 µl


Supplier: Thermo Scientific
Description: Potassium vinyltrifluoroborate 95%

Supplier: Brady
Description: Make labels that withstand up to 10 years of outdoor abuse with this low-shrink vinyl label material (B-595). Print almost anywhere with a durable Brady handheld label printer.

Catalog Number: (BOSSBS-9104R-A750)
Supplier: Bioss
Description: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognised by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.
UOM: 1 * 100 µl


Supplier: Merck
Description: Polyethylene glycol 300 for synthesis, Sigma-Aldrich®

Catalog Number: (92500.290)
Supplier: VWR Chemicals
Description: VWR® PFAS grade LC-MS solvents undergo a rigorous use test to ensure suitability for analysis of poly- and perfluoroalkyl substances resulting in an ultra low background of PFAS analytes. Using complementary methods a broad range of PFAS analytes are quantified to their detection limits by LC-MS.
UOM: 1 * 1 L

Supplier: APOLLO SCIENTIFIC
Description: Intermediate for the synthesis of poly(arylene ether phenylquinoxanlines): ACS Symp. Ser. 407, 212, 1999

Supplier: Brady
Description: B-417 high-adhesion self-laminating vinyl wraps are designed for tough conditions, including high-humidity environments, small diameter wires, and newer wire jacketing materials.

Supplier: Alfa Aesar
Description: Polyethyleneimine, M.W. 25,000, linear
Supplier: Brady
Description: Permanent vinyl (B-439) is a thermal transfer printable material ideal for applications needing various colours like finished product ID, rating plates, and general-purpose ID.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 88 22222.
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