You Searched For: block+heaters+

Catalog Number: (BOSSBS-0431R-CY7)

Supplier: Bioss

Description: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF1/TRAIL and protect against apoptosis. TNFSF1/TRAIL binding blocks the inhibition of osteoclastogenesis.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-5323R)

Supplier: Bioss

Description: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-0492R-CY5.5)

Supplier: Bioss

Description: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.

UOM: 1 * 100 µl

Catalog Number: (BRDY170949)

Supplier: Brady

Description: These are made from durable, low-shrink vinyl with a very aggressive adhesive. The labels adhere to irregular, curved, rough and highly textured surfaces (painted cinder blocks, uneven wood, textured plastics, paper jacketed pipes, powder coated surfaces). Also adhere to difficult low energy surface items (PVC piping, blow-moulded equipment cases, ABS plastics, recycled plastics).

UOM: 1 * 1 items

Catalog Number: (BOSSBS-13334R)

Supplier: Bioss

Description: Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-6480R-A488)

Supplier: Bioss

Description: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-6480R-FITC)

Supplier: Bioss

Description: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-6480R-A555)

Supplier: Bioss

Description: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-2608R-CY5)

Supplier: Bioss

Description: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-11859R-FITC)

Supplier: Bioss

Description: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-9047R-A680)

Supplier: Bioss

Description: Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarisation and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid <i>in vitro</i>. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.

UOM: 1 * 100 µl

Supplier: WARTEWIG

Description: Fuego SCS and Fuego SCS pro gas safety burners have the latest safety technology. Thanks to their innovative design and an extensive range of standard equipment, these laboratory gas burners are suitable for all applications that require a flame in the laboratory. The low profile housing allows you to work in comfort, and the streamlined design reduces the impact of air currents on clean room workbenches. The SCS (safety control system) uses the latest safety technology, constantly analysing potential dangers and triggering protective measures when necessary - such as the interruption of the gas supply. After prolonged use a residual heat indicator signals that the burner head is still hot, to help to prevent burns. Made entirely of stainless steel, and thanks to its fireproof controls and a display protected by special glass, the Fuego SCS can withstand even extreme laboratory conditions.

Catalog Number: (BOSSBS-7885R-CY7)

Supplier: Bioss

Description: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.Tissue specificity: Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-7885R-CY5)

Supplier: Bioss

Description: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.Tissue specificity: Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-13334R-A350)

Supplier: Bioss

Description: Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-13334R-A488)

Supplier: Bioss

Description: Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded.

UOM: 1 * 100 µl