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Catalog Number: (BOSSBS-4877R-A350)

Supplier: Bioss

Description: The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-9414R-CY5)

Supplier: Bioss

Description: NET-4, also known as TSPAN5 or TM4SF9, is a 268 amino acid multi-pass membrane protein that belongs to the tetraspanin family and is thought to play a role in signal transduction events related to cell development, activation, growth and motility. The gene encoding NET-4 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-11496R-FITC)

Supplier: Bioss

Description: Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity).

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-15102R-A750)

Supplier: Bioss

Description: C20orf186

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-5657R-CY7)

Supplier: Bioss

Description: This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene. [provided by RefSeq].

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-13552R-FITC)

Supplier: Bioss

Description: ZBED2

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-7925R-A680)

Supplier: Bioss

Description: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.Tissue specificity: Widely expressed. Present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. Also found in adult cell lines.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-5506R-CY7)

Supplier: Bioss

Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK11 is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-3755R-CY7)

Supplier: Bioss

Description: Crkl is a 34kDa adaptor protein which has been shown to activate the RAS and JUN kinase signalling pathways and transforms fibroblasts in a RAS dependant manner. Crkl is a substitute of BCR ABL tyrosine kinase. In addition, Crkl has oncogenic potential.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-3181R-CY5.5)

Supplier: Bioss

Description: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-0008R-PE)

Supplier: Bioss

Description: Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-9270R-CY5.5)

Supplier: Bioss

Description: Anti-BEND5 Rabbit Polyclonal Antibody (Cy5.5®)

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-2721R-A488)

Supplier: Bioss

Description: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-9306R-HRP)

Supplier: Bioss

Description: Phosphorylated upon DNA damage, probably by ATM or ATR.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-5959R-A555)

Supplier: Bioss

Description: Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Four known isoforms exist.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-7686R-CY7)

Supplier: Bioss

Description: May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.

UOM: 1 * 100 µl