You Searched For: LY-83583

Catalog Number: (BOSSBS-0392R-A750)

Supplier: Bioss

Description: Sequence: H-Arg-Lys-Asp-Val-Tyr-OH<br>MW: 679,8.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-6921R-FITC)

Supplier: Bioss

Description: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-3051R-CY7)

Supplier: Bioss

Description: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-6921R-A750)

Supplier: Bioss

Description: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognises 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-7735R-A350)

Supplier: Bioss

Description: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.

UOM: 1 * 100 µl

Supplier: BLD PHARMATECH GMBH

Description: D-Lysine 98%

Catalog Number: (BLDPBD226676-50MG)

Supplier: BLD PHARMATECH GMBH

Description: 2-Methyl-5,10-dihydro-4H-benzo[b]thieno[2,3-e][1,4]diazepin-4-one 96%

UOM: 1 * 50 mg

Catalog Number: (BOSSBS-6478R)

Supplier: Bioss

Description: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-0392R-CY5)

Supplier: Bioss

Description: Sequence:: H-Arg-Lys-Asp-Val-Tyr-OH
MW: 679.12

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-0392R-CY5.5)

Supplier: Bioss

Description: Sequence:: H-Arg-Lys-Asp-Val-Tyr-OH
MW: 679.13

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-6921R-CY5.5)

Supplier: Bioss

Description: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-11921R-A680)

Supplier: Bioss

Description: Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me).

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-6921R-A647)

Supplier: Bioss

Description: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-11866R-A555)

Supplier: Bioss

Description: Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-0392R-A555)

Supplier: Bioss

Description: Sequence:: H-Arg-Lys-Asp-Val-Tyr-OH
MW: 679.8

UOM: 1 * 100 µl

Catalog Number: (BOSSBS-3051R-A350)

Supplier: Bioss

Description: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.

UOM: 1 * 100 µl