Description: Defects in ATXN3 are the cause of spinocerebellar ataxia type 3 (SCA3) ; also known as Machado-Joseph disease (MJD). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA3 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. The molecular defect in SCA3 is the a CAG repeat expansion in ATXN3 coding region. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.

Catalog Number: BOSSBS-4807R-FITC

UOM: 1 * 100 µl

Supplier: Bioss

Sale

Description: Rugged compact moisture analysers with large backlit dot matrix graphic display for moisture determination of raw materials and finished products in the food, cosmetics, dairy, pharmaceutical, chemical agriculture, construction and ceramics industries.

Catalog Number: 611-4489

UOM: 1 * 1 items

Supplier: VWR Collection

Sale

Description: Sabouraud dextrose broth (SDB) is a liquid medium used in qualitative procedures for isolation of yeasts and moulds and for the culture or subculture of fungi from clinical and nonclinical specimens.

Catalog Number: LIOF402040

UOM: 1 * 1 items

Supplier: LIOFILCHEM

Sale

Description: A no-rinse hygienic hand rub that feels great to use and is clinically proven to maintain skin health.

Catalog Number: 115-0553

UOM: 1 * 2 items

Supplier: GOJO Industries - Europe Ltd

Sale

Description: Defects in ATXN3 are the cause of spinocerebellar ataxia type 3 (SCA3) ; also known as Machado-Joseph disease (MJD). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA3 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. The molecular defect in SCA3 is the a CAG repeat expansion in ATXN3 coding region. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.

Catalog Number: BOSSBS-4807R-A555

UOM: 1 * 100 µl

Supplier: Bioss

Sale

Description: Defects in ATXN3 are the cause of spinocerebellar ataxia type 3 (SCA3) ; also known as Machado-Joseph disease (MJD). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA3 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. The molecular defect in SCA3 is the a CAG repeat expansion in ATXN3 coding region. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.

Catalog Number: BOSSBS-4807R-A350

UOM: 1 * 100 µl

Supplier: Bioss

Sale

Description: A hygienic, no-rinse hand rub that feels great to use and is clinically proven to maintain skin health.

Catalog Number: 115-2992

UOM: 1 * 2 items

Supplier: GOJO Industries - Europe Ltd

Sale

Description: IPI-549 is a selective phosphoinositide-3-kinase (PI3K)-γ inhibitor with IC50 of 16 nM as an immuno-oncology clinical candidate.

Catalog Number: APOSBISN0153-10MG

UOM: 1 * 10 mg

Supplier: APOLLO SCIENTIFIC

Sale

Description: Safety lancets for blood glucose and other<i> in vitro</i> diagnostic tests.

Catalog Number: MODU371213

UOM: 1 * 100 items

Supplier: Vitrex Medical A/S

New Product Sale

Description: Moisture analyser

Catalog Number: YSS43-02

UOM: 1 * 1 items

Supplier: Sartorius Balances

Sale

Description: VWR® Disposable cleanroom socks are designed to provide all day comfort inside a cleanroom. They are made from materials that prevent any particle generation while in use.

Catalog Number: 114-9707

UOM: 1 * 400 PAIR

Supplier: VWR Collection

New Product Sale

Description: IMAGEN™ is a qualitative direct immunofluorescence test used for detection and confirmation of the presence of virus in cell culture or in clinical specimen.

Catalog Number: OXOIS610930-2

UOM: 1 * 1 items

Supplier: THERMO FISHER DIAGNOSTICS

Sale

Description: Defects in ATXN3 are the cause of spinocerebellar ataxia type 3 (SCA3) ; also known as Machado-Joseph disease (MJD). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA3 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. The molecular defect in SCA3 is the a CAG repeat expansion in ATXN3 coding region. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.

Catalog Number: BOSSBS-4807R

UOM: 1 * 100 µl

Supplier: Bioss

Sale

Description: This MAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Catalog Number: BNUB0844-100

UOM: 1 * 100 µl

Supplier: Biotium

Sale

Description: This MAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Catalog Number: BNC470674-100

UOM: 1 * 100 µl

Supplier: Biotium

Sale

Description: This MAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Catalog Number: BNCB0674-100

UOM: 1 * 100 µl

Supplier: Biotium

Sale